Comfort Inn Edwardsville

About Us

Whether you're visiting Southern Illinois University Edwardsville, exploring historic Route 66, or planning a day trip into St. Louis, we're here to provide a comfortable and relaxing place to call home. Conveniently located just off Interstate 270, our hotel offers easy access to many of the area's most popular attractions while giving you a welcoming place to unwind after a day on the road.

Start your morning with our complimentary hot breakfast, stay connected with free Wi-Fi, or take a refreshing dip in our indoor heated pool before continuing your journey. With spacious guest rooms, modern amenities, and friendly service, we're proud to welcome travelers, families, business guests, and Route 66 adventurers looking for a comfortable stay in Edwardsville.

Get Directions