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Museums in Missouri

Neon Museum of Saint Louis

1. Neon Museum of Saint Louis

3537 Chouteau Ave, St. Louis, MO

Collection of restored neon signs from mid-century STL.

Museums Specialty/Niche
Missouri History Museum

2. Missouri History Museum

5700 Lindell Blvd, St. Louis, MO

Museum showcasing Missouri’s diverse history, including Route 66 and STL heritage exhibits.

Museums Local History
National Museum of Transportation

3. National Museum of Transportation

2933 Barrett Station Rd, St. Louis, MO

One of the largest collections of transportation vehicles in the world.

Museums Transportation/Auto
Joplin History & Mineral Museum

4. Joplin History & Mineral Museum

504 S Schifferdecker Ave, Joplin, MO

Local museum featuring mining history, Route 66 exhibits, and sports memorabilia.

Museums Local History Specialty/Niche
Jesse James Wax Museum

5. Jesse James Wax Museum

I-44, Stanton, MO

A wax museum dedicated to the infamous outlaw Jesse James.

Museums Specialty/Niche
Toy Museum

6. Toy Museum

I-44, Exit 230, Sullivan, MO

Former roadside toy museum with vintage toys and collectibles—now closed.

Museums Specialty/Niche
Route 66 Museum - MO

7. Route 66 Museum - MO

915 S Jefferson Ave, Lebanon, MO

Museum preserving Route 66 history and culture.

Museums Route 66 Museums
Route 66 Car Museum

8. Route 66 Car Museum

1634 W College St, Springfield, MO

Car museum with vintage and classic vehicles on display.

Museums Transportation/Auto
Battle of Carthage Civil War Museum

9. Battle of Carthage Civil War Museum

205 Grant St, Carthage, MO

Museum interpreting the Civil War Battle of Carthage and regional history.

Museums Historic Sites Local History Regional Museums
Red Cedar Inn Museum & Visitor Center

10. Red Cedar Inn Museum & Visitor Center

1047 E Osage St, Pacific, MO

Museum and visitor center inside a historic 1930s motor inn.

Museums Route 66 Museums
Joplin Historical Neighborhoods Museum

11. Joplin Historical Neighborhoods Museum

422 S Sergeant Ave, Joplin, MO

Museum showcasing the history of Joplin’s neighborhoods, architecture, and community development.

Museums Local History
Rosati Winery Museum

12. Rosati Winery Museum

22050 State Hwy KK, Saint James, MO

Once a charming winery and museum—closed but a reminder of local viticulture.

Museums Specialty/Niche